Water → 1H-Benzimidazole-4-carbohydrazide
반응식
C[O:2][C:3]([C:5]1[C:10]2[N:11]=[CH:12][NH:13][C:9]=2[CH:8]=[CH:7][CH:6]=1)=O.O.[NH2:15][NH2:16].O>CCO>[N:11]1[C:10]2[C:5]([C:3]([NH:15][NH2:16])=[O:2])=[CH:6][CH:7]=[CH:8][C:9]=2[NH:13][CH:12]=1참가 물질
5
실험 절차
Benzimidazole ester 3 (1.65 g, 9.36 mmol), hydrazine monohydrate (10 mL), and water (3 mL) were refluxed in EtOH (60 mL) for 24 hs. Reaction mixture was cooled to room temperature and solid formed was filtered, washed with EtOH and dried to give 1.13 g (68%) of pure 4: 1H NMR (DMSO-d6) δ 12.31 (br.s, 1H), 10.59 (s, 1H), 8.44 (s, 1H), 7.86 (d, 1H, J=6.5 Hz), 7.76 (d, 1H, J=8.0 Hz), 7.34 (t, 1H, J=8.0 Hz), 4.68 (s, 2H).
후처리
- customReaction mixture
- customsolid formed
- filtrationwas filtered
- washwashed with EtOH
- customdried
- customto give 1.13 g (68%) of pure 4
출처 및 근거
- ORD 기록
- ord-6a4dd83572c947db8f9a9740f2244af9
- 출처 데이터셋
- uspto-grants-2007_06
- 특허 번호
- US07235557B2
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