Triphenylphosphine → {6-[2-(4-Methyl-2-phenyl-thiazol-5-yl)-ethoxy]-indol-1-yl}-acetic acid tert-butyl ester

HRID 1767932

반응식

HRID 1767932 반응식
[C:1]([O:5][C:6](=[O:18])[CH2:7][N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([OH:17])[CH:15]=2)[CH:10]=[CH:9]1)([CH3:4])([CH3:3])[CH3:2].[CH3:19][C:20]1[N:21]=[C:22]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[S:23][C:24]=1[CH2:25][CH2:26]O.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.N(C(OC(C)(C)C)=O)=NC(OC(C)(C)C)=O>>[C:1]([O:5][C:6](=[O:18])[CH2:7][N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([O:17][CH2:26][CH2:25][C:24]3[S:23][C:22]([C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=4)=[N:21][C:20]=3[CH3:19])[CH:15]=2)[CH:10]=[CH:9]1)([CH3:4])([CH3:2])[CH3:3]

참가 물질

5

반응물 4

HCID 11776TriphenylphosphineHCID 97268Di-tert-butyl azodicarboxylateHCID 226476342-(4-Methyl-2-phenyl-1,3-thiazol-5-yl)ethan-1-olHCID 69283069tert-Butyl (6-hydroxy-1H-indol-1-yl)acetate

생성물 1

HCID 69280396{6-[2-(4-Methyl-2-phenyl-thiazol-5-yl)-ethoxy]-indol-1-yl}-acetic acid tert-butyl ester

실험 절차

In analogy to the procedure described in example 3 c], (6-hydroxy-indol-1-yl)-acetic acid tert-butyl ester (example 6 b]) was reacted with 2-(4-methyl-2-phenyl-thiazol-5-yl)-ethanol [U. H. Lindberg, G. Bexell, B. Ulff, Acta Pharmaceutica Suecica 1971, 8, 49-58] in the presence of triphenylphosphine and di-tert-butyl azodicarboxylate to yield {6-[2-(4-methyl-2-phenyl-thiazol-5-yl)-ethoxy]-indol-1-yl}-acetic acid tert-butyl ester as colorless oil.

출처 및 근거

ORD 기록
ord-e8305fb81bea4061811de0be8548c16b
출처 데이터셋
uspto-grants-2007_06
특허 번호
US07235572B2

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