Lithium Hydroxide → {6-[5-Methyl-2-(4-trifluoromethyl-phenyl)-thiazol-4-ylmethoxy]-indol-1-yl}-acetic acid
반응식
C([O:5][C:6](=[O:35])[CH2:7][N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([O:17][CH2:18][C:19]3[N:20]=[C:21]([C:25]4[CH:30]=[CH:29][C:28]([C:31]([F:34])([F:33])[F:32])=[CH:27][CH:26]=4)[S:22][C:23]=3[CH3:24])[CH:15]=2)[CH:10]=[CH:9]1)(C)(C)C.[Li+].[OH-]>>[CH3:24][C:23]1[S:22][C:21]([C:25]2[CH:30]=[CH:29][C:28]([C:31]([F:33])([F:32])[F:34])=[CH:27][CH:26]=2)=[N:20][C:19]=1[CH2:18][O:17][C:14]1[CH:15]=[C:16]2[C:11]([CH:10]=[CH:9][N:8]2[CH2:7][C:6]([OH:35])=[O:5])=[CH:12][CH:13]=1참가 물질
3
실험 절차
In analogy to the procedure described in example 2 c], {6-[5-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-4-ylmethoxy]-indol-1-yl}-acetic acid tert-butyl ester was treated with LiOH to obtain {6-[5-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-4-ylmethoxy]-indol-1-yl}-acetic acid as yellow solid.
출처 및 근거
- ORD 기록
- ord-2387bec6853045ea834c296587188703
- 출처 데이터셋
- uspto-grants-2007_06