Lithium Hydroxide → {6-[2-(5-Methyl-2-phenyl-thiazol-4-yl)-ethoxy]-indol-1-yl}-acetic acid
반응식
C([O:5][C:6](=[O:32])[CH2:7][N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([O:17][CH2:18][CH2:19][C:20]3[N:21]=[C:22]([C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=4)[S:23][C:24]=3[CH3:25])[CH:15]=2)[CH:10]=[CH:9]1)(C)(C)C.[Li+].[OH-]>>[CH3:25][C:24]1[S:23][C:22]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)=[N:21][C:20]=1[CH2:19][CH2:18][O:17][C:14]1[CH:15]=[C:16]2[C:11]([CH:10]=[CH:9][N:8]2[CH2:7][C:6]([OH:32])=[O:5])=[CH:12][CH:13]=1참가 물질
3
실험 절차
In analogy to the procedure described in example 2 c], {6-[2-(5-methyl-2-phenyl-thiazol-4-yl)-ethoxy]-indol-1-yl}-acetic acid tert-butyl ester was treated with LiOH to obtain {6-[2-(5-methyl-2-phenyl-thiazol-4-yl)-ethoxy]-indol-1-yl}-acetic acid as colorless solid.
출처 및 근거
- ORD 기록
- ord-d4503c40b88d4ce79e534de78516deed
- 출처 데이터셋
- uspto-grants-2007_06
- 특허 번호
- US07235572B2
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