Lithium Hydroxide → {6-[2-(3-Fluoro-4-trifluoromethyl-phenyl)-4-methyl-thiazol-5-ylmethoxy]-indol-1-yl}-acetic acid
반응식
C([O:5][C:6](=[O:36])[CH2:7][N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([O:17][CH2:18][C:19]3[S:23][C:22]([C:24]4[CH:29]=[CH:28][C:27]([C:30]([F:33])([F:32])[F:31])=[C:26]([F:34])[CH:25]=4)=[N:21][C:20]=3[CH3:35])[CH:15]=2)[CH:10]=[CH:9]1)(C)(C)C.[Li+].[OH-]>>[F:34][C:26]1[CH:25]=[C:24]([C:22]2[S:23][C:19]([CH2:18][O:17][C:14]3[CH:15]=[C:16]4[C:11]([CH:10]=[CH:9][N:8]4[CH2:7][C:6]([OH:36])=[O:5])=[CH:12][CH:13]=3)=[C:20]([CH3:35])[N:21]=2)[CH:29]=[CH:28][C:27]=1[C:30]([F:32])([F:31])[F:33]참가 물질
3
실험 절차
In analogy to the procedure described in example 2 c], {6-[2-(3-fluoro-4-trifluoromethyl-phenyl)-4-methyl-thiazol-5-ylmethoxy]-indol-1-yl}-acetic acid tert-butyl ester was treated with LiOH to obtain {6-[2-(3-fluoro-4-trifluoromethyl-phenyl)-4-methyl-thiazol-5-ylmethoxy]-indol-1-yl}-acetic acid as off-white solid.
출처 및 근거
- ORD 기록
- ord-80738ea2b6184a46ab60994a61ba8e33