2-Hydroxyquinoline → 3-(Hydroxymethylidene)-1-phenylquinoline-2,4(1H,3H)-dione

반응식

[C:1]1([N:7]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[C:10]([OH:17])=[CH:9][C:8]2=[O:18])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.N1C2C(=CC=CC=2)C=C[C:20]1=[O:29]>>[C:1]1([N:7]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[C:10]([OH:17])=[C:9]([CH:20]=[O:29])[C:8]2=[O:18])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

반응물 2

HCID 60382-Hydroxyquinoline

HCID 546761614-Hydroxy-1-phenyl-1,2-dihydroquinolin-2-one

생성물 1

HCID 1354542273-(Hydroxymethylidene)-1-phenylquinoline-2,4(1H,3H)-dione

실험 절차

Following the procedure set forth in Preparation B, 1- phenyl-4-hydroxy-2(1H)-quinolinone was converted to 1 -phenyl-3-formyl-4-hydroxy-(2(1H)-quinolinone. That the expected product was obtained was confirmed by the spectral data: MS: m/e 265 (M·+); NMR (DMSO): δ10.08 (s, 1H, CHO) ppm.

출처 및 근거

ORD 기록: ord-65a4b71350594840aa49ee2192ba0d7d
출처 데이터셋: uspto-grants-1995_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05378694

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