Benzoyl Peroxide → 1-(1-Bromoethyl)-4-(trimethylsilyl)benzene

HRID 1768561노트

반응식

HRID 1768561 반응식
[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([Si:9]([CH3:12])([CH3:11])[CH3:10])=[CH:5][CH:4]=1)[CH3:2].[Br:13]N1C(=O)CCC1=O.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C(Cl)(Cl)(Cl)Cl>[Br:13][CH:1]([C:3]1[CH:8]=[CH:7][C:6]([Si:9]([CH3:10])([CH3:12])[CH3:11])=[CH:5][CH:4]=1)[CH3:2]

참가 물질

5

반응물 3

HCID 7187Benzoyl PeroxideHCID 67184N-bromobutanimideHCID 280168(4-Ethylphenyl)trimethylsilane

생성물 1

HCID 189488471-(1-Bromoethyl)-4-(trimethylsilyl)benzene수율 91%

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매

실험 절차

The product of Step A (59 g, 0.33 mole) was dissolved in carbon tetrachloride (700 mL). To this solution was added N-bromosuccinimide (59 g, 0.33 mole) and benzoyl peroxide (ca. 200 rag) in one portion. The reaction mixture was heated to reflux for 2.5 hours while being irradiated with a 275 watt sunlamp. After cooling, the solid succinimide was removed by filtration and the filtrate was washed with saturated aqueous NaHSO3. Drying (MgSO4) and concentration gave an oil (77 g, 91% yield) which was used in the next step without further purification.

후처리

  1. temperatureThe reaction mixture was heated
  2. temperatureto reflux for 2.5 hours
  3. customwhile being irradiated with a 275 watt sunlamp
  4. temperatureAfter cooling
  5. customthe solid succinimide was removed by filtration
  6. washthe filtrate was washed with saturated aqueous NaHSO3
  7. customDrying
  8. concentration(MgSO4) and concentration

출처 및 근거

ORD 기록
ord-e41c25baefde4f14adf9090dc61d831a
출처 데이터셋
uspto-grants-1995_01
특허 번호
US05378708

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