Hydrazine hydrate (1:1) → 3-(2-Pyridyl)propanoic acid, hydrazide
반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][CH2:8][C:9]([O:11]CC)=O.O.[NH2:15][NH2:16]>CCO>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][CH2:8][C:9]([NH:15][NH2:16])=[O:11]참가 물질
4
실험 절차
To a stirring 5 mL EtOH solution of 0.58 g (3.2 mmol) of ethyl 3-(2-pyridinyl)propanoate (4), prepared as described above in Example 4, was added 0.32 g (6.5 mmol) of hydrazine hydrate. The reaction was heated at reflux for three weeks. Although the reaction was still incomplete, the solvent was removed under vacuum. The resulting gum was triturated with diethyl ether (Et2O). The product remained a gum. The yield of 3-(2-pyridyl)propanoic acid, hydrazide (5) was 0.22 g (42%). This product was used immediately in the manner described in Example 6 below.
후처리
- temperatureThe reaction was heated
- temperatureat reflux for three weeks
- customthe solvent was removed under vacuum
- customThe resulting gum was triturated with diethyl ether (Et2O)
출처 및 근거
- ORD 기록
- ord-86e4953eb0aa43dcba89d42b69a4c7d9
- 출처 데이터셋
- uspto-grants-1995_01
- 특허 번호
- US05378840
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