N-(1-(2-(3,4-dimethoxyphenyl)ethyl)pyrrolidin-3-yl)phthalimide → 3-Amino-1-(2-(3,4-dimethoxyphenyl)ethyl)pyrrolidine

HRID 1769674

반응식

HRID 1769674 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:11][CH2:12][N:13]2[CH2:17][CH2:16][CH:15]([N:18]3C(=O)C4=CC=CC=C4C3=O)[CH2:14]2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]>C(O)C.O.NN>[NH2:18][CH:15]1[CH2:16][CH2:17][N:13]([CH2:12][CH2:11][C:5]2[CH:6]=[CH:7][C:8]([O:9][CH3:10])=[C:3]([O:2][CH3:1])[CH:4]=2)[CH2:14]1

참가 물질

4

반응물 1

HCID 15045352N-(1-(2-(3,4-dimethoxyphenyl)ethyl)pyrrolidin-3-yl)phthalimide

생성물 1

HCID 150453533-Amino-1-(2-(3,4-dimethoxyphenyl)ethyl)pyrrolidine수율 100.3%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 24654Hydrazine hydrate (1:1)용매

실험 절차

1.03 g of N-(1-(2-(3,4-dimethoxyphenyl)ethyl)pyrrolidin-3-yl)phthalimide was dissolved in 50 ml of ethanol, to which 2 ml of hydrazine monohydrate was added and refluxed under heating for 14 hours. The solvent was distilled off and an aqueous diluted solution of sodium hydroxide was added to the residue and extracted with chloroform. After drying with anhydrous magnesium sulfate, the solvent was distilled off, to obtain 0.68 g of the above-captioned compound (yield: 100%).

후처리

  1. additionwas added
  2. temperaturerefluxed
  3. temperatureunder heating for 14 hours
  4. distillationThe solvent was distilled off
  5. additionan aqueous diluted solution of sodium hydroxide was added to the residue
  6. extractionextracted with chloroform
  7. dry with materialAfter drying with anhydrous magnesium sulfate
  8. distillationthe solvent was distilled off

출처 및 근거

ORD 기록
ord-2b898912e44e4185a91be783ed3b8d64
출처 데이터셋
uspto-grants-1995_01
특허 번호
US05382595

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