Water → 1,2-Diphenylethyl-N-methylamine

HRID 1769824

반응식

HRID 1769824 반응식
[H-].[Al+3].[Li+].[H-].[H-].[H-].[C:7]([NH:12][CH:13]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)(OCC)=O.O.[OH-].[Na+]>O1CCCC1>[CH3:7][NH:12][CH:13]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

참가 물질

6

반응물 4

HCID 962Water2회HCID 14798Sodium HydroxideHCID 234956Ethyl (1,2-diphenylethyl)carbamateHCID 21226445Aluminium lithium hydride

생성물 1

HCID 1109861,2-Diphenylethyl-N-methylamine

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

To a stirred suspension of lithium aluminum hydride (12.4 g, 0.032 mol) in 300 ml of tetrahydrofuran at 0 C. under nitrogen was added dropwise a solution of N-carboethoxy-1,2-diphenylethylamine (35.0 g, 0.13 mmol) in 200 ml of tetrahydrofuran. The mixture was heated to reflux for 8 hours. The mixture was cooled in an ice-water bath and water (13 ml), 15% NaOH (13 ml) and water (39 ml) were carefully added to the mixture. The mixture was warmed to ambient temperature and the precipitated salts were removed by filtration through celite. Removal of solvent gave N-methyl-1,2-diphenylethylamine, 26.8 g as a colorless oil.

후처리

  1. temperatureThe mixture was heated
  2. temperatureto reflux for 8 hours
  3. temperatureThe mixture was cooled in an ice-water bath
  4. customthe precipitated salts were removed by filtration through celite
  5. customRemoval of solvent

출처 및 근거

ORD 기록
ord-2d9c928fa747469485ee53b9057e0637
출처 데이터셋
uspto-grants-1995_01
특허 번호
US05382683

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