Water → 4-(4-Bromophenyl)-6,7-dimethoxy-2-naphthol

HRID 1771515노트

반응식

HRID 1771515 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=O)[CH2:9][C:10](=[O:22])[CH2:11][C:12]2[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[C:14]([O:20][CH3:21])[CH:13]=2)=[CH:4][CH:3]=1.O>P(=O)(O)(O)O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:17]3[C:12](=[CH:13][C:14]([O:20][CH3:21])=[C:15]([O:18][CH3:19])[CH:16]=3)[CH:11]=[C:10]([OH:22])[CH:9]=2)=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 962WaterHCID 591887201-(4-Bromophenyl)-4-(3,4-dimethoxyphenyl)butane-1,3-dione

생성물 1

HCID 591887014-(4-Bromophenyl)-6,7-dimethoxy-2-naphthol수율 90%

시약·촉매·용매 1

HCID 1004Phosphoric Acid용매

실험 절차

1-(4-Bromophenyl)-4-(3,4-dimethoxyphenyl)butane-1,3-dione (3 g, 8 mmol) in 85% phosphoric acid was heated at 70° C. for 20 h. The resulting solution was cooled, poured into water (150 ml) and filtered. The residue was dissolved in dichloromethane (50 ml), washed with water (50 ml), dried (MgSO4) and the solvent was removed under reduced pressure to give the title compound (2.56 g, 90%) as a brown powder.

후처리

  1. temperatureThe resulting solution was cooled
  2. filtrationfiltered
  3. dissolutionThe residue was dissolved in dichloromethane (50 ml)
  4. washwashed with water (50 ml)
  5. dry with materialdried (MgSO4)
  6. customthe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-c2da843f6db24b4d942af4ae76a03635
출처 데이터셋
uspto-grants-2016_02
특허 번호
US09249136B2

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