Methyl iodide → 1,3-Dichloro-4-methoxy-2-nitrobenzene
반응식
[Cl:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[C:6]([Cl:11])[CH:5]=[CH:4][C:3]=1[OH:12].[C:13]([O-])([O-])=O.[K+].[K+].CI>CC(C)=O>[Cl:11][C:6]1[CH:5]=[CH:4][C:3]([O:12][CH3:13])=[C:2]([Cl:1])[C:7]=1[N+:8]([O-:10])=[O:9]참가 물질
5
실험 절차
To a solution of 2,4-dichloro-3-nitro-phenol (600 mg, 2.9 mmol, 1.0 eq) in acetone (30 mL), was added K2CO3 (1.2 g, 8.7 mmol, 3.0 eq) and the solution was stirred at room temperature for 30 min. Methyl iodide (1.2 g, 8.7 mmol, 3.0 eq) was added and the reaction was stirred at room temperature overnight. The reaction was filtered to remove the inorganic salts and the organic phase was evaporated in vacuo to give the title compound (550 mg, 86%).
후처리
- stirringthe reaction was stirred at room temperature overnight
- filtrationThe reaction was filtered
- customto remove the inorganic salts
- customthe organic phase was evaporated in vacuo
출처 및 근거
- ORD 기록
- ord-7074dac009fa46b0a988e9fe93fd5563
- 출처 데이터셋
- uspto-grants-2016_02
- 특허 번호
- US09249085B2
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