4-(Dibenzofuran-2-yloxy)-1-nitrobenzene → 4-(Dibenzofuran-2-yloxy)aniline

HRID 17720

반응식

HRID 17720 반응식
[CH:1]1[C:9]2[C:8]3[CH:10]=[CH:11][CH:12]=[CH:13][C:7]=3[O:6][C:5]=2[CH:4]=[CH:3][C:2]=1[O:14][C:15]1[CH:20]=[CH:19][C:18]([N+:21]([O-])=O)=[CH:17][CH:16]=1>CCOC(C)=O.[Pd]>[CH:1]1[C:9]2[C:8]3[CH:10]=[CH:11][CH:12]=[CH:13][C:7]=3[O:6][C:5]=2[CH:4]=[CH:3][C:2]=1[O:14][C:15]1[CH:20]=[CH:19][C:18]([NH2:21])=[CH:17][CH:16]=1

참가 물질

4

반응물 1

HCID 21028934-(Dibenzofuran-2-yloxy)-1-nitrobenzene

생성물 1

HCID 669774564-(Dibenzofuran-2-yloxy)aniline

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

The nitro intermediate (10 mmol) obtained above was dissolved in EtOAc (50 mL) and hydrogenated in the presence of 10% Pd/C (360 mg) until completion according to General Procedure H, as indicated by TLC or HPLC. The reaction mixture was then filtered to remove the catalyst. The solvent was removed in vacuuo to afford the desired 4-(dibenzofuran-2-yloxy)aniline, which was used directly for further transformation without further purification.

후처리

  1. filtrationThe reaction mixture was then filtered
  2. customto remove the catalyst
  3. customThe solvent was removed in vacuuo

출처 및 근거

ORD 기록
ord-5f9ed205d452444faefb95035ce5c199
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07737285B2

연결된 노트

불러오는 중…