Acetonitrile → HCID 117902772, 화합물

HRID 1772171노트

반응식

HRID 1772171 반응식
[CH3:1][C:2]1[N:3]=[C:4]2[CH:9]=[CH:8][CH:7]=[C:6]([CH3:10])[N:5]2[CH:11]=1.[I:12]N1C(=O)CCC1=O.C(#N)C>C(Cl)Cl>[I:12][C:11]1[N:5]2[C:6]([CH3:10])=[CH:7][CH:8]=[CH:9][C:4]2=[N:3][C:2]=1[CH3:1]

참가 물질

5

반응물 3

HCID 6342AcetonitrileHCID 120273N-IodosuccinimideHCID 1386822,5-Dimethylimidazo(1,2-a)pyridine

생성물 1

HCID 117902772HCID 117902772, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A mixture of 2,5-dimethylimidazo[1,2-a]pyridine (0.5 g, 3.4 mmol), N-iodosuccinimide (770 mg, 3.4 mmol) and ACN (5 ml) is stirred at RT for 45 minutes. The mixture is diluted with DCM and extracted with an aqueous solution sodium thiosulfate. The combined organic layers are dried over MgSO4 and concentrated in vacuo. The product is purified by RP HPLC. Yield: 775 mg (83%). HPLC-MS: M+H=273; tR=1.02 min (METHOD—1).

후처리

  1. extractionextracted with an aqueous solution sodium thiosulfate
  2. dry with materialThe combined organic layers are dried over MgSO4
  3. concentrationconcentrated in vacuo
  4. customThe product is purified by RP HPLC

출처 및 근거

ORD 기록
ord-039d71eed34f48048ad1f5b66bb0b01a
출처 데이터셋
uspto-grants-2016_02
특허 번호
US09249151B2

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