2-Chloromethyl 2-(trimethylsilyl)ethyl ether → HCID 131734178, 화합물

반응식

[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12](=[O:13])[NH:11][N:10]=[N:9]2)=[CH:4][CH:3]=1.[CH3:14][Si:15]([CH2:18][CH2:19][O:20][CH2:21]Cl)([CH3:17])[CH3:16]>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[C:12](=[O:13])[N:11]([CH2:21][O:20][CH2:19][CH2:18][Si:15]([CH3:17])([CH3:16])[CH3:14])[N:10]=[N:9]2)=[CH:6][CH:7]=1

참가 물질

반응물 2

HCID 27242712-Chloromethyl 2-(trimethylsilyl)ethyl ether

HCID 1362439061-(4-Bromophenyl)-1,2-dihydro-5H-tetrazol-5-one

생성물 1

HCID 131734178HCID 131734178, 화합물수율 81%

실험 절차

Compound 14a (5.00 g, 20.7 mmol) was treated with SEMCl using the reaction conditions described in Example 10, Step C to obtain compound 14b as a white solid (6.90 g, 81% yield). Mass Spectrum (LCMS, ESI pos.): Calcd. for C13H19BrN4O2Si: 371.0 (M+H). Found 371.1.

후처리

customthe reaction conditions

출처 및 근거

ORD 기록: ord-e6d8628660f44cc88b9417a5057bca3b
출처 데이터셋: uspto-grants-2016_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09249163B2

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