Ammonium Hydroxide → 6-Bromo-3-chloropyrazin-2-amine

HRID 1772747

반응식

HRID 1772747 반응식
Br[C:2]1[C:3]([Cl:9])=[N:4][CH:5]=[C:6]([Br:8])[N:7]=1.[NH4+:10].[OH-]>>[Br:8][C:6]1[N:7]=[C:2]([NH2:10])[C:3]([Cl:9])=[N:4][CH:5]=1

참가 물질

3

반응물 2

HCID 14923Ammonium HydroxideHCID 533503583,5-Dibromo-2-chloropyrazine

생성물 1

HCID 569657236-Bromo-3-chloropyrazin-2-amine수율 66%

반응 조건

온도
100 °C

실험 절차

Into a 250 mL sealed tube was placed compound 90d (50.0 g, 184 mmol) and NH4OH (150 mL). The resulting mixture was stirred overnight at 100° C. Upon cooling, a solid was collected by filtration and dried in an oven under reduced pressure to obtain the compound 90e as a grey solid (28.0 g, 66% yield), which was used in next step without further purification.

후처리

  1. customInto a 250 mL sealed tube
  2. temperatureUpon cooling
  3. filtrationa solid was collected by filtration
  4. customdried in an oven under reduced pressure

출처 및 근거

ORD 기록
ord-d5f3122d6ae94ffd963d262464e523f4
출처 데이터셋
uspto-grants-2016_02
특허 번호
US09249163B2

연결된 노트

불러오는 중…