Stannous Chloride → 2-amino-4-fluoro-N-[3-(methylsulfanyl)phenyl]benzenesulfonamide

반응식

[F:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([S:18][CH3:19])[CH:13]=2)(=[O:10])=[O:9])=[C:4]([N+:20]([O-])=O)[CH:3]=1.Cl[Sn]Cl>>[NH2:20][C:4]1[CH:3]=[C:2]([F:1])[CH:7]=[CH:6][C:5]=1[S:8]([NH:11][C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([S:18][CH3:19])[CH:13]=1)(=[O:9])=[O:10]

참가 물질

반응물 2

HCID 24479Stannous Chloride

HCID 269524144-fluoro-N-[3-(methylsulfanyl)phenyl]-2-nitrobenzenesulfonamide

생성물 1

HCID 292684342-amino-4-fluoro-N-[3-(methylsulfanyl)phenyl]benzenesulfonamide수율 98.8%

실험 절차

The title compound (780 mg, 2.50 mmol) was prepared from 4-fluoro-N-[3-(methylsulfanyl)phenyl]-2-nitrobenzenesulfonamide (865 mg, 2.53 mmol) and SnCl2 (1.44 g, 7.59 mmol) using the methods of (IntA1), Step 2.

출처 및 근거

ORD 기록: ord-b56b9b41823243ff8424867673c11cce
출처 데이터셋: uspto-grants-2016_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09249160B2

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