Ethyl Acetate → 6-hydrazino-1-isobutyl-3-methyl-2,4(1H,3H)-pyrimidinedione

HRID 1773333

반응식

HRID 1773333 반응식
Cl[C:2]1[N:7]([CH2:8][CH:9]([CH3:11])[CH3:10])[C:6](=[O:12])[N:5]([CH3:13])[C:4](=[O:14])[CH:3]=1.CCOC(C)=O.O.[NH2:22][NH2:23]>CCO>[NH:22]([C:2]1[N:7]([CH2:8][CH:9]([CH3:11])[CH3:10])[C:6](=[O:12])[N:5]([CH3:13])[C:4](=[O:14])[CH:3]=1)[NH2:23]

참가 물질

5

반응물 3

HCID 8857Ethyl AcetateHCID 24654Hydrazine hydrate (1:1)HCID 52825666-Chloro-1-isobutyl-3-methylpyrimidine-2,4(1H,3H)-dione

생성물 1

HCID 193560846-hydrazino-1-isobutyl-3-methyl-2,4(1H,3H)-pyrimidinedione수율 100%

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

To a solution of 6-chloro-1-isobutyl-3-methylpyrimidine-2,4(1H,3H)-dione (2.0 g 9.3 mmol) in EtOH (8 mL), hydrazine monohydrate (1.3 mL) in EtOH (3 mL) is added slowly. The reaction mixture is refluxed for 5 hours, and then cooled. A large amount of AcOEt is added into the reaction mixture, and then cooled and filtered to give 1.95 g of product as yellowish solids (Yield: 100%).

후처리

  1. temperatureThe reaction mixture is refluxed for 5 hours
  2. temperaturecooled
  3. temperaturecooled
  4. filtrationfiltered

출처 및 근거

ORD 기록
ord-cc2896e7097f4b2fa3b58388d8ef9e97
출처 데이터셋
uspto-grants-2016_02
특허 번호
US09255099B2

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