Potassium Carbonate → 3-Methoxy-4-nitroaniline
반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH:12]C(=O)C)[CH:6]=[CH:7][C:8]=1[N+:9]([O-:11])=[O:10].C(=O)([O-])[O-].[K+].[K+]>Cl>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH2:12])[CH:6]=[CH:7][C:8]=1[N+:9]([O-:11])=[O:10]참가 물질
4
실험 절차
A mixture of N-(3-methoxy-4-nitro-phenyl)-acetamide (16.6 g, 78.67 mmol) and an aqueous solution of hydrochloric acid (1.5 M, 200 mL) was refluxed until a clear solution was obtained. The reaction mixture was basified by addition of an aqueous solution of potassium carbonate and then was extracted four times with dichloromethane (200 mL); the combined organic extracts were dried over anhydrous sodium sulfate, filtered and evaporated under reduced pressure to give 13.56 g (quantitative yield) of 3-methoxy-4-nitro-phenylamine as a yellow solid. MS=169 [M+H]+.
후처리
- customwas obtained
- extractionwas extracted four times with dichloromethane (200 mL)
- dry with materialthe combined organic extracts were dried over anhydrous sodium sulfate
- filtrationfiltered
- customevaporated under reduced pressure
출처 및 근거
- ORD 기록
- ord-ac32929e6bcd4527ae67a65748c8fc93
- 출처 데이터셋
- uspto-grants-2016_02
- 특허 번호
- US09255110B2
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