Phosphorus oxychloride → 2-Chloro-7-methoxy-6-nitro-quinoline

반응식

[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[CH:8][C:9](=O)[NH:10]2)=[CH:5][C:4]=1[N+:14]([O-:16])=[O:15].P(Cl)(Cl)([Cl:19])=O>>[Cl:19][C:9]1[CH:8]=[CH:7][C:6]2[C:11](=[CH:12][C:3]([O:2][CH3:1])=[C:4]([N+:14]([O-:16])=[O:15])[CH:5]=2)[N:10]=1

참가 물질

반응물 2

HCID 24813Phosphorus oxychloride

HCID 580563477-methoxy-6-nitro-1H-quinolin-2-one

생성물 1

HCID 580562092-Chloro-7-methoxy-6-nitro-quinoline

반응 조건

온도: 110 °C

실험 절차

A mixture of 7-methoxy-6-nitro-1H-quinolin-2-one (0.13 g) and phosphorus oxychloride (1 mL) was heated at 110° C. for 2 hours. The resulting mixture was then cooled and poured into ice. The solid which formed was collected by filtration and dried under vacuum to afford 0.119 g of 2-chloro-7-methoxy-6-nitro-quinoline as a brown solid.

후처리

temperatureThe resulting mixture was then cooled
additionpoured into ice
customThe solid which formed
filtrationwas collected by filtration
customdried under vacuum

출처 및 근거

ORD 기록: ord-671a9647a21c45c09945b4809225bf4c
출처 데이터셋: uspto-grants-2016_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09255110B2

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