Hydrochloric Acid → HCID 86705348, 화합물

HRID 1773633노트

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HRID 1773633 반응식
[O:1]1CCO[CH:2]1[C:6]1[CH:11]=[CH:10][C:9]([C:12]2[N:16]3[N:17]=[C:18]([C:26]4[CH:31]=[CH:30][N:29]=[CH:28][CH:27]=4)[CH:19]=[C:20]([NH:21][CH2:22][CH:23]([CH3:25])[CH3:24])[C:15]3=[N:14][CH:13]=2)=[CH:8][CH:7]=1.Cl.C(=O)([O-])O>CC(C)=O>[CH2:22]([NH:21][C:20]1[C:15]2[N:16]([C:12]([C:9]3[CH:8]=[CH:7][C:6]([CH:2]=[O:1])=[CH:11][CH:10]=3)=[CH:13][N:14]=2)[N:17]=[C:18]([C:26]2[CH:27]=[CH:28][N:29]=[CH:30][CH:31]=2)[CH:19]=1)[CH:23]([CH3:25])[CH3:24]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 769Bicarbonate IonHCID 66695628HCID 66695628, 화합물

생성물 1

HCID 86705348HCID 86705348, 화합물수율 73%

시약·촉매·용매 1

HCID 180Acetone용매

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온도
23 °C

실험 절차

To a solution of 63 mg (152 μmol) 3-[4-(1,3-dioxolan-2-yl)phenyl]-N-isobutyl-6-(pyridin-4-yl)imidazo[1,2-b]pyridazin-8-amine which was prepared according to intermediate example 13b, in 2.8 mL acetone were added 190 μL 4N hydrochloric acid and the mixture was stirred at 23° C. for 2 hours. Saturated hydrogen carbonate solution was added and the mixture was extracted with dichloromethane. The organic phase was dried over sodium sulfate. After filtration and removal of solvent the residue was purified by chromatography to give 41 mg (73%) of the title compound.

후처리

  1. extractionthe mixture was extracted with dichloromethane
  2. dry with materialThe organic phase was dried over sodium sulfate
  3. filtrationAfter filtration and removal of solvent the residue
  4. customwas purified by chromatography

출처 및 근거

ORD 기록
ord-15b4ee5810864cefa9b39179ba15eb75
출처 데이터셋
uspto-grants-2016_02
특허 번호
US09255100B2

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