Methylamine → Benzoic acid, 2-(methylamino)-3-nitro-, methyl ester

HRID 1773741

반응식

HRID 1773741 반응식
F[C:2]1[C:11]([N+:12]([O-:14])=[O:13])=[CH:10][CH:9]=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5].C(=O)([O-])[O-].[K+].[K+].[CH3:21][NH2:22]>C(Cl)Cl.O>[CH3:21][NH:22][C:2]1[C:11]([N+:12]([O-:14])=[O:13])=[CH:10][CH:9]=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5]

참가 물질

6

반응물 3

HCID 6329MethylamineHCID 11430Potassium CarbonateHCID 13470961Methyl 2-fluoro-3-nitrobenzoate

생성물 1

HCID 59635415Benzoic acid, 2-(methylamino)-3-nitro-, methyl ester

시약·촉매·용매 2

HCID 962Water용매HCID 6344Dichloromethane용매

실험 절차

Methyl 2-fluoro-3-nitrobenzoate (25 g, 0.126 mol) was dissolved in DCM (400 ml) and to this was added Potassium carbonate (34.7 g, 0.25 mol) followed by Methylamine (20.63 ml, 0.5 mol). Reaction was stirred at room temperature under argon. Upon completion reaction was diluted with water and extracted with DCM (3×) then dried over magnesium sulfate. Solvents were removed under reduced pressure to afford methyl 2-(methylamino)-3-nitrobenzoate as a yellow solid.

후처리

  1. customReaction
  2. customUpon completion reaction
  3. extractionextracted with DCM (3×)
  4. dry with materialthen dried over magnesium sulfate
  5. customSolvents were removed under reduced pressure

출처 및 근거

ORD 기록
ord-7b54cf94915f4dfb8c875f28ccffe5d3
출처 데이터셋
uspto-grants-2016_02
특허 번호
US09255089B2

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