Hydrochloric Acid → 3-Methyl-3-phenylbutan-2-one

HRID 1773908노트

반응식

HRID 1773908 반응식
CON(C)[C:4](=[O:14])[C:5]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)([CH3:7])[CH3:6].[Li]C.[CH3:18]COCC.Cl>C1COCC1>[CH3:6][C:5]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)([CH3:7])[C:4](=[O:14])[CH3:18]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 59788661N-Methoxy-N-methyl-2-phenyl-isobutyramideHCID 178418348HCID 178418348, 화합물

생성물 1

HCID 2854623-Methyl-3-phenylbutan-2-one

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of N-methoxy-N-methyl-2-phenyl-isobutyramide (example 207E) (16 g, 77.2 mmoles) in THF (300 mL) cooled at −50° C. is added dropwise a 1.6M solution of MeLi in Et2O (80 mL, 131.2 mmoles). The reaction mixture is allowed to reach 0° C. and 1N HCl (130 mL, 130 mmoles) is added. The aqueous phase is extracted with Et2O. The organic phase is washed with brine, dried over MgSO4, filtered and the solvent is removed under reduced pressure to give 3-methyl-3-phenyl-butan-2-one.

후처리

  1. customto reach 0° C.
  2. extractionThe aqueous phase is extracted with Et2O
  3. washThe organic phase is washed with brine
  4. dry with materialdried over MgSO4
  5. filtrationfiltered
  6. customthe solvent is removed under reduced pressure

출처 및 근거

ORD 기록
ord-df5282149dc0482aa6d17b1b3e2c6c34
출처 데이터셋
uspto-grants-2016_02
특허 번호
US09255101B2

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