Formamide → 6-Chloroquinazolin-4-amine

HRID 1774109

반응식

HRID 1774109 반응식
[NH2:1][C:2]1[CH:9]=[CH:8][C:7]([Cl:10])=[CH:6][C:3]=1[C:4]#[N:5].O.[CH:12]([NH2:14])=O>>[NH2:5][C:4]1[C:3]2[C:2](=[CH:9][CH:8]=[C:7]([Cl:10])[CH:6]=2)[N:1]=[CH:12][N:14]=1

참가 물질

4

반응물 3

HCID 713FormamideHCID 962WaterHCID 800192-Amino-5-chlorobenzonitrile

생성물 1

HCID 3202476-Chloroquinazolin-4-amine수율 95%

실험 절차

A solution of 2-amino-5-chlorobenzonitrile (1.07 g, 7.0 mmol) in formamide (20 ml) was heated at 180° C. for 6 hours. After cooling to room temperature, water (30 ml) was added to the reaction mixture. The precipitate was collected by filtration, washed with water and dried over P2O5, yielding the title compound as a grey solid (1.2 g, yield: 95%) which was characterized by its mass spectrum as follows: MS (m/z): 180 ([M+H]+, 100).

후처리

  1. filtrationThe precipitate was collected by filtration
  2. washwashed with water
  3. dry with materialdried over P2O5

출처 및 근거

ORD 기록
ord-7961d86c3b52443c9f46bd36712cb397
출처 데이터셋
uspto-grants-2016_02
특허 번호
US09259426B2

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