Water → 2-{5-cyclopropyl-1-[4-(difluoromethoxy)-2,6-difluorobenzyl]-4-methyl-1H-pyrazol-3-yl}-5-methoxy-N-(pyridin-4-yl)pyrimidin-4-amine

반응식

[CH:1]1([C:4]2[NH:8][N:7]=[C:6]([C:9]3[N:14]=[C:13]([NH:15][C:16]4[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=4)[C:12]([O:22][CH3:23])=[CH:11][N:10]=3)[C:5]=2[CH3:24])[CH2:3][CH2:2]1.[H-].[Na+].Br[CH2:28][C:29]1[C:34]([F:35])=[CH:33][C:32]([O:36][CH:37]([F:39])[F:38])=[CH:31][C:30]=1[F:40].O>C1COCC1>[CH:1]1([C:4]2[N:8]([CH2:28][C:29]3[C:30]([F:40])=[CH:31][C:32]([O:36][CH:37]([F:38])[F:39])=[CH:33][C:34]=3[F:35])[N:7]=[C:6]([C:9]3[N:14]=[C:13]([NH:15][C:16]4[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=4)[C:12]([O:22][CH3:23])=[CH:11][N:10]=3)[C:5]=2[CH3:24])[CH2:3][CH2:2]1