Hydrochloric Acid → 3-((4-Propylcyclohexyl)cyclohexyl)phenyl propanoate

HRID 17751노트

반응식

HRID 17751 반응식
[C:1](Cl)(=[O:4])[CH2:2][CH3:3].[CH2:6]([CH:9]1[CH2:14][CH2:13][CH:12]([C:15]2([C:21]3[CH:22]=[C:23]([OH:27])[CH:24]=[CH:25][CH:26]=3)[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]2)[CH2:11][CH2:10]1)[CH2:7][CH3:8].O.Cl>N1C=CC=CC=1>[C:1]([O:27][C:23]1[CH:24]=[CH:25][CH:26]=[C:21]([C:15]2([CH:12]3[CH2:13][CH2:14][CH:9]([CH2:6][CH2:7][CH3:8])[CH2:10][CH2:11]3)[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]2)[CH:22]=1)(=[O:4])[CH2:2][CH3:3]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 62324Propionyl chlorideHCID 684282843-((4-Propylcyclohexyl)cyclohexyl)phenol

생성물 1

HCID 684297793-((4-Propylcyclohexyl)cyclohexyl)phenyl propanoate수율 109.9%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

Under a nitrogen atmosphere, 1.7 g of propanoyl chloride was added to 5.0 g of 3-((4-propylcyclohexyl)cyclohexyl)phenol (3) dissolved in 10 mL of pyridine under cooling with iced water, and after completing dropwise addition, the mixture was stirred at ambient temperature for 2 hours. The resulting solution was added to 20 mL of 3N hydrochloric acid. The aqueous layer was extracted with diethyl ether, which was added to the organic layer, and the organic layer was washed with a saturated salt solution and then dried over anhydrous magnesium sulfate. The solvent was distilled off to obtain 6.52 g of 3-((4-propylcyclohexyl)cyclohexyl)phenyl propanoate (4).

후처리

  1. additionaddition
  2. extractionThe aqueous layer was extracted with diethyl ether, which
  3. additionwas added to the organic layer
  4. washthe organic layer was washed with a saturated salt solution
  5. dry with materialdried over anhydrous magnesium sulfate
  6. distillationThe solvent was distilled off

출처 및 근거

ORD 기록
ord-40c8bef0bc5d470f8c1c4b99c8dc2dc8
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07740769B2

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