Monosodium Citrate → Tofacitinib Citrate

HRID 1775142

반응식

HRID 1775142 반응식
[CH3:1][C@H:2]1[C@@H:7]([N:8]([C:10]2[N:18]=[CH:17][N:16]=[C:15]3[C:11]=2[CH:12]=[CH:13][NH:14]3)[CH3:9])[CH2:6][N:5]([C:19]([CH2:21][C:22]#[N:23])=[O:20])[CH2:4][CH2:3]1.Br.[C:25]([O-:37])(=[O:36])[CH2:26][C:27]([CH2:32][C:33]([OH:35])=[O:34])([C:29]([OH:31])=[O:30])[OH:28].[Na+]>O>[CH3:1][C@H:2]1[C@@H:7]([N:8]([C:10]2[N:18]=[CH:17][N:16]=[C:15]3[C:11]=2[CH:12]=[CH:13][NH:14]3)[CH3:9])[CH2:6][N:5]([C:19]([CH2:21][C:22]#[N:23])=[O:20])[CH2:4][CH2:3]1.[CH2:32]([C:27]([OH:28])([C:29]([OH:31])=[O:30])[CH2:26][C:25]([OH:37])=[O:36])[C:33]([OH:35])=[O:34]

참가 물질

4

반응물 2

HCID 23666341Monosodium CitrateHCID 131734730HCID 131734730, 화합물

생성물 1

HCID 10174505Tofacitinib Citrate수율 89.3%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
25 °C

실험 절차

Amorphous tofacitinib hydrobromide (0.55 g) was dissolved in water (6 mL). The solution was treated with solid monosodium citrate (0.40 g, 1.69 mmol) and the resulting white suspension was stirred for 16 hours at 25° C. The suspension was filtered, washed with water (2×5 mL) and air-dried for 16 hours at 25° C. to yield 0.63 g of tofacitinib citrate as a white solid.

후처리

  1. filtrationThe suspension was filtered
  2. washwashed with water (2×5 mL)
  3. customair-dried for 16 hours at 25° C.

출처 및 근거

ORD 기록
ord-749e280bbddb45d38834f9f5890e8c66
출처 데이터셋
uspto-grants-2016_02
특허 번호
US09260438B2

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