Hydrochloric Acid → 1-(5-Methyl-1,2,4-oxadiazol-3-yl)piperazine hydrochloride

HRID 1775321노트

반응식

HRID 1775321 반응식
[CH3:1][C:2]1[O:6][N:5]=[C:4]([N:7]2[CH2:12][CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9][CH2:8]2)[N:3]=1.[ClH:20].O1CCOCC1>C(OCC)C>[ClH:20].[CH3:1][C:2]1[O:6][N:5]=[C:4]([N:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)[N:3]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 86686046tert-Butyl 4-(5-methyl-1,2,4-oxadiazol-3-yl)piperazine-1-carboxylate

생성물 1

HCID 866860471-(5-Methyl-1,2,4-oxadiazol-3-yl)piperazine hydrochloride

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

To a solution of tert-butyl 4-(5-methyl-1,2,4-oxadiazol-3-yl)piperazine-1-carboxylate (507 mg, 1.890 mmol) in diethyl ether (12 mL) was added HCl, 4N in dioxane (7 mL, 28.0 mmol) and the reaction was stirred at room temperature over the weekend. The precipitate was isolated by filtration, washed with diethylether and dried under reduced pressure after which 330 mg of a white solid were obtained (1.612 mmol, 85%). MS (ESI) m/z=169.2 [M+1]+.

후처리

  1. customThe precipitate was isolated by filtration
  2. washwashed with diethylether
  3. dry with materialdried under reduced pressure after which 330 mg of a white solid
  4. customwere obtained (1.612 mmol, 85%)

출처 및 근거

ORD 기록
ord-d9037ac3eb424c3290e27dfc9adeecb1
출처 데이터셋
uspto-grants-2016_02
특허 번호
US09260441B2

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