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Hydrochloric Acid → 1-(4-Methylpyridin-2-YL)-1,4-diazepane dihydrochloride

HRID 1775336
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HRID 1775336 반응식
[CH3:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([N:8]2[CH2:14][CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10][CH2:9]2)[CH:3]=1.[ClH:22]>C(Cl)Cl>[ClH:22].[ClH:22].[CH3:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([N:8]2[CH2:14][CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[CH:3]=1
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참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 131734736Tert-butyl 4-(4-methylpyridin-2-yl)-1,4-diazepane-1-carboxylate

생성물 1

HCID 898257101-(4-Methylpyridin-2-YL)-1,4-diazepane dihydrochloride수율 101.9%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

tert-Butyl 4-(4-methyl-2-pyridyl)-1,4-diazepane-1-carboxylate (91 mg, 0.312 mmol) was dissolved in DCM under nitrogen. Hydrochloric acid (4N in dioxane, 1.56 ml, 6.25 mmol) was added and the mixture was stirred at room temperature overnight. The mixture was evaporated under reduced pressure to give 84 mg of a solid (quantitative). MS (ESI) m/z=192.2 [M+1]+.

후처리

  1. customThe mixture was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-a280c5f7ab0341599c4603ad1af6eb67
출처 데이터셋
uspto-grants-2016_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09260441B2

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