Hydrochloric Acid → Ethyl 5-(methylamino)-2-(piperazin-1-yl)thiazole-4-carboxylate hydrochloride

HRID 1775355노트

반응식

HRID 1775355 반응식
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[S:15][C:16]([NH:24][CH3:25])=[C:17]([C:19]([O:21][CH2:22][CH3:23])=[O:20])[N:18]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:26]>C(OCC)C.C(O)C>[ClH:26].[CH3:25][NH:24][C:16]1[S:15][C:14]([N:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)=[N:18][C:17]=1[C:19]([O:21][CH2:22][CH3:23])=[O:20]

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 89825828Ethyl 2-(4-tert-butoxycarbonylpiperazin-1-yl)-5-methylamino-thiazole-4-carboxylate

생성물 1

HCID 89826078Ethyl 5-(methylamino)-2-(piperazin-1-yl)thiazole-4-carboxylate hydrochloride

시약·촉매·용매 2

HCID 702Ethanol용매HCID 3283Diethyl Ether용매

실험 절차

Ethyl 2-(4-tert-butoxycarbonylpiperazin-1-yl)-5-methylamino-thiazole-4-carboxylate (196 mg, 0.529 mmol) was dissolved in a mixture of diethylether (10 ml) and ethanol (absolute, 15 ml), hydrochloric acid (4N in dioxane, 5 ml) was added and the mixture was stirred at room temperature for two days. The resulting precipitate was collected by filtration, washed with diethylether and dried under reduced pressure to give 130 mg of a white solid (0.424 mmol, yield 80) MS (multi-mode) m/z=271.1 [M+1]+.

후처리

  1. additionwas added
  2. filtrationThe resulting precipitate was collected by filtration
  3. washwashed with diethylether
  4. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-2713baebf79c484eb0207233db39d5c9
출처 데이터셋
uspto-grants-2016_02
특허 번호
US09260441B2

반응 노트

불러오는 중…