1,1'-Carbonyldiimidazole → hexahydroimidazo[1,5-a]pyridin-3(2H)-one

HRID 1775508

반응식

HRID 1775508 반응식
C1N=CN([C:6](N2C=NC=C2)=[O:7])C=1.[NH:13]1[CH2:18][CH2:17][CH2:16][CH2:15][CH:14]1[CH2:19][NH2:20]>C(Cl)Cl>[CH2:19]1[CH:14]2[CH2:15][CH2:16][CH2:17][CH2:18][N:13]2[C:6](=[O:7])[NH:20]1

참가 물질

4

반응물 2

HCID 682631,1'-CarbonyldiimidazoleHCID 90865Piperidine-2-methylamine

생성물 1

HCID 47002315hexahydroimidazo[1,5-a]pyridin-3(2H)-one

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of CDI (830 mg, 5.1 mmol) and piperidin-2-ylmethanamine (520 mg, 4.6 mmol) in DCM (20 mL) was stirred at room temperature overnight. After the solvent was removed, the residue was directly used for the next step without further purification.

후처리

  1. customAfter the solvent was removed
  2. customthe residue was directly used for the next step without further purification

출처 및 근거

ORD 기록
ord-619ee6518b044e9c8f2128490bba4c10
출처 데이터셋
uspto-grants-2016_02
특허 번호
US09260452B2

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