4-Chloroaniline → 3-(4-Chlorophenyl)-7-phenylthieno[3,2-d]pyrimidin-4(3H)-one

HRID 1775608

반응식

HRID 1775608 반응식
[C:1]1([N:7]2[C:12](=[O:13])[C:11]3[S:14][CH:15]=[C:16]([C:17]4[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=4)[C:10]=3[N:9]=[CH:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.NC1C(C2C=CC=CC=2)=CSC=1C(OC)=O.C(OCC)(OCC)OCC.[Cl:49]C1C=CC(N)=CC=1>C(O)(=O)C>[Cl:49][C:4]1[CH:5]=[CH:6][C:1]([N:7]2[C:12](=[O:13])[C:11]3[S:14][CH:15]=[C:16]([C:17]4[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=4)[C:10]=3[N:9]=[CH:8]2)=[CH:2][CH:3]=1

참가 물질

6

반응물 4

HCID 78124-ChloroanilineHCID 31214Ethyl orthoformateHCID 2759782Methyl 3-amino-4-phenylthiophene-2-carboxylateHCID 783248653,7-Diphenylthieno[3,2-d]pyrimidin-4(3H)-one

생성물 1

HCID 783248713-(4-Chlorophenyl)-7-phenylthieno[3,2-d]pyrimidin-4(3H)-one수율 36%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

In the same manner as the synthesis of Compound 1, methyl 3-amino-4-phenylthiophene-2-carboxylate (60 mg, 0.26 mmol), triethyl orthoformate (0.5 ml), 4-chloroaniline (61 mg, 0.48 mmol), and acetic acid (0.06 ml) were used to give 31.6 mg (0.093 mmol, 36% yield) of the title compound.

출처 및 근거

ORD 기록
ord-5a958cc719064c4fa99885c901bb0df5
출처 데이터셋
uspto-grants-2016_02
특허 번호
US09260448B2

연결된 노트

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