1-(4-Bromo-3-methylphenyl)ethanone → 2-Bromo-1-(4-bromo-3-methylphenyl)ethanone

HRID 1776025

반응식

HRID 1776025 반응식
[Br-:1].[Br-].[Br-].C[N+](C)(C)C1C=CC=CC=1.C[N+](C1C=CC=CC=1)(C)C.C[N+](C1C=CC=CC=1)(C)C.[Br:34][C:35]1[CH:40]=[CH:39][C:38]([C:41](=[O:43])[CH3:42])=[CH:37][C:36]=1[CH3:44]>C1COCC1>[Br:1][CH2:42][C:41]([C:38]1[CH:39]=[CH:40][C:35]([Br:34])=[C:36]([CH3:44])[CH:37]=1)=[O:43]

참가 물질

4

반응물 2

HCID 3471241-(4-Bromo-3-methylphenyl)ethanoneHCID 17977687Phenyltrimethylammonium bromide dibromide

생성물 1

HCID 591663462-Bromo-1-(4-bromo-3-methylphenyl)ethanone수율 100%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Trimethyl phenylammonium tribromide (13 g, 0.036 mol) was added to a solution of 1-(4-bromo-3-methyl-phenyl)-ethanone (6.3 g, 0.030 mol) in THF (30 mL) and the reaction mixture was stirred at RT for 12 h, filtered, and concentrated to provide the title intermediate (8.6 g, 100% yield). 1H NMR (CDCl3, 400 MHz) δ (ppm): 7.82 (m, 1H), 7.66 (m, 2H), 4.38 (s, 2H), 2.56 (s, 3H)

후처리

  1. filtrationfiltered
  2. concentrationconcentrated

출처 및 근거

ORD 기록
ord-f045d3a9eb774e919dd2222e64f2203e
출처 데이터셋
uspto-grants-2016_02
특허 번호
US09260414B2

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