Cesium carbonate → ethyl 4-({2-[1-(4-ethoxy-2,6-difluorobenzyl)-1H-indazol-3-yl]-5-methoxypyrimidin-4-yl}amino)pyridine-3-carboxylate

반응식

[CH2:1]([O:3][C:4]1[CH:28]=[C:27]([F:29])[C:7]([CH2:8][N:9]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[C:11]([C:18]3[N:23]=[C:22]([NH2:24])[C:21]([O:25][CH3:26])=[CH:20][N:19]=3)=[N:10]2)=[C:6]([F:30])[CH:5]=1)[CH3:2].Cl[C:32]1[C:37]([C:38]([O:40][CH2:41][CH3:42])=[O:39])=[CH:36][N:35]=[CH:34][CH:33]=1.CC1(C)C2C=CC=C(P(C3C=CC=CC=3)C3C=CC=CC=3)C=2OC2C1=CC=CC=2P(C1C=CC=CC=1)C1C=CC=CC=1.C(=O)([O-])[O-].[Cs+].[Cs+]>O1CCOCC1.C([O-])(=O)C.C([O-])(=O)C.[Pd+2]>[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([F:30])[C:7]([CH2:8][N:9]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[C:11]([C:18]3[N:23]=[C:22]([NH:24][C:32]4[CH:33]=[CH:34][N:35]=[CH:36][C:37]=4[C:38]([O:40][CH2:41][CH3:42])=[O:39])[C:21]([O:25][CH3:26])=[CH:20][N:19]=3)=[N:10]2)=[C:27]([F:29])[CH:28]=1)[CH3:2]