HCID 86679502, 화합물 → HCID 86679503, 화합물

HRID 1776547노트

반응식

HRID 1776547 반응식
[CH3:1][O:2][C:3]1[CH:18]=[CH:17][C:6]([C:7]([O:9]CC2C=CC=CC=2)=[O:8])=[CH:5][C:4]=1[N:19]([CH2:24][CH2:25][N:26]1[CH2:31][CH2:30][O:29][CH2:28][CH2:27]1)[S:20]([CH3:23])(=[O:22])=[O:21]>CO.C(Cl)(Cl)Cl.[Pd]>[CH3:1][O:2][C:3]1[CH:18]=[CH:17][C:6]([C:7]([OH:9])=[O:8])=[CH:5][C:4]=1[N:19]([CH2:24][CH2:25][N:26]1[CH2:31][CH2:30][O:29][CH2:28][CH2:27]1)[S:20]([CH3:23])(=[O:22])=[O:21]

참가 물질

5

반응물 1

HCID 86679502HCID 86679502, 화합물

생성물 1

HCID 86679503HCID 86679503, 화합물수율 58.5%

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 887Methanol용매2회HCID 6212Chloroform용매

실험 절차

Benzyl 4-methoxy-3-(N-(2-morpholinoethyl)methylsulfonamido)benzoate (1.5 g, 3.34 mmol) was dissolved in MeOH (20 ml), then Pd/C 5% (0.33 mmol, 702 mg) was added, and the mixture was hydrogenated in a Parr apparatus (H2:35 psi) for 30 minutes. The reaction was diluted with CHCl3 (300 ml) and MeOH (300 ml) to dissolve the product that precipitated in MeOH, and the catalyst was filtered over a celite pad, and the solvent is evaporated under vacuum, to yield 700 mg of white solid.

후처리

  1. dissolutionto dissolve the product that
  2. customprecipitated in MeOH
  3. filtrationthe catalyst was filtered over a celite pad
  4. customthe solvent is evaporated under vacuum

출처 및 근거

ORD 기록
ord-1805dc38ee514846a54527a777e199ab
출처 데이터셋
uspto-grants-2016_02
특허 번호
US09265768B2

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