Sodium Hydroxide → 2-[2-(Methylsulfonyl)phenoxy]acetic acid

HRID 1777133노트

반응식

HRID 1777133 반응식
[CH3:1][S:2]([C:5]1[CH:17]=[CH:16][CH:15]=[CH:14][C:6]=1[O:7][CH2:8][C:9]([O:11]CC)=[O:10])(=[O:4])=[O:3].[OH-].[Na+]>CCO>[CH3:1][S:2]([C:5]1[CH:17]=[CH:16][CH:15]=[CH:14][C:6]=1[O:7][CH2:8][C:9]([OH:11])=[O:10])(=[O:3])=[O:4]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 86729449Ethyl 2-(2-(methylsulfonyl)phenoxy)acetate

생성물 1

HCID 232741362-[2-(Methylsulfonyl)phenoxy]acetic acid

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of ethyl 2-(2-(methylsulfonyl)phenoxy)acetate (750 mg, 2.9 mmol) in EtOH (15 ml) was added 10% NaOH aqueous solution (15 mL) at 26° C. The mixture was stirred for 30 min and then concentrated and the residue diluted with water (20 mL) and washed with ethyl acetate (2×20 mL). The aqueous layer was then acidified with 2N HCL until pH 3 and then extracted with ethyl acetate (2×20 ml). The combined organic layers were washed with brine (30 mL), dried over Na2SO4 and concentrated to give the title compound which was used in next step without further purification.

후처리

  1. concentrationconcentrated
  2. additionthe residue diluted with water (20 mL)
  3. washwashed with ethyl acetate (2×20 mL)
  4. extractionextracted with ethyl acetate (2×20 ml)
  5. washThe combined organic layers were washed with brine (30 mL)
  6. dry with materialdried over Na2SO4
  7. concentrationconcentrated

출처 및 근거

ORD 기록
ord-d08681aa5c65423f8d4dfafcb2d8ae4e
출처 데이터셋
uspto-grants-2016_02
특허 번호
US09266836B2

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