Sodium Chlorite → 3-chloro-4-(2-methylpropyl)Benzoic acid

HRID 1777335

반응식

HRID 1777335 반응식
Cl([O-])=O.[Na+].[OH2:5].O.P([O-])(O)(O)=O.[Na+].[Cl:13][C:14]1[CH:15]=[C:16]([CH:19]=[CH:20][C:21]=1[CH2:22][CH:23]([CH3:25])[CH3:24])[CH:17]=[O:18]>O.C(O)(C)(C)C>[Cl:13][C:14]1[CH:15]=[C:16]([CH:19]=[CH:20][C:21]=1[CH2:22][CH:23]([CH3:25])[CH3:24])[C:17]([OH:5])=[O:18]

참가 물질

6

반응물 3

HCID 23668197Sodium ChloriteHCID 23673460Sodium Phosphate, Monobasic, DihydrateHCID 867151403-Chloro-4-isobutylbenzaldehyde

생성물 1

HCID 593167203-chloro-4-(2-methylpropyl)Benzoic acid

시약·촉매·용매 2

HCID 962Water용매HCID 6386tert-Butanol용매

실험 절차

A mixture of sodium chlorite (80% assay, 1.06 g, 0.0094 mol) and sodium dihydrogenphosphate dihydrate (3.33 g, 0.0213 mol) in demineralized water (10 mL) is added in two equal lots (one hr interval) to a solution of 3-chloro-4-isobutylbenzaldehyde (0.7 g, 0.0036 mol) in tert-butanol (10 mL) at room temperature. After completion of addition, stirring at room temperature is continued for 4 hrs. It is then extracted in ethyl acetate (2×30 mL). Combined organic layer is dried over sodium sulfate and concentrated under reduced pressure to give 3-chloro-4-isobutylbenzoic acid.

후처리

  1. additionAfter completion of addition
  2. extractionIt is then extracted in ethyl acetate (2×30 mL)
  3. dry with materialCombined organic layer is dried over sodium sulfate
  4. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-ff7706cd72734ce494cce9d11fc0e1c1
출처 데이터셋
uspto-grants-2016_02
특허 번호
US09266867B2

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