Hydrochloric Acid → HCID 58970539, 화합물
반응식
Cl.C(OC([N:9]1[CH2:14][CH2:13][C:12]([CH2:18][CH:19]([CH3:21])[CH3:20])([C:15]([OH:17])=[O:16])[CH2:11][CH2:10]1)=O)(C)(C)C>O1CCOCC1>[CH2:18]([C:12]1([C:15]([OH:17])=[O:16])[CH2:11][CH2:10][NH:9][CH2:14][CH2:13]1)[CH:19]([CH3:21])[CH3:20]참가 물질
4
실험 절차
A solution of hydrochloric acid (12N, 1.2 mL) in 1,4-dioxane (2.4 mL) is added to 4-isobutylpiperidine-1,4-dicarboxylic acid monotertbutyl ester (0.7 g, 0.0025 mol) and stirred at room temperature for 1 hr. The reaction mixture is concentrated under reduced pressure and the residue is treated with saturated solution of sodium bicarbonate (0.5 mL) to adjust the pH to ˜7. It is again concentrate under reduced pressure to get crude 4-isobutylpiperidine-4-carboxylic acid.
후처리
- concentrationThe reaction mixture is concentrated under reduced pressure
- additionthe residue is treated with saturated solution of sodium bicarbonate (0.5 mL)
- concentrationIt is again concentrate under reduced pressure
출처 및 근거
- ORD 기록
- ord-f1695c4a314746b992d4439a3af5c3e0
- 출처 데이터셋
- uspto-grants-2016_02
- 특허 번호
- US09266867B2
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