Triphenylphosphine → 2-(5-(trifluoromethyl)-1H-indol-3-yl)ethanamine

HRID 1777545노트

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HRID 1777545 반응식
[N:1]([CH2:4][CH2:5][C:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([C:15]([F:18])([F:17])[F:16])[CH:13]=2)[NH:8][C:7]=1[Si](CC)(CC)CC)=[N+]=[N-].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>CO>[F:17][C:15]([F:16])([F:18])[C:12]1[CH:13]=[C:14]2[C:9](=[CH:10][CH:11]=1)[NH:8][CH:7]=[C:6]2[CH2:5][CH2:4][NH2:1]

참가 물질

4

반응물 2

HCID 11776TriphenylphosphineHCID 866638363-(2-azidoethyl)-2-(triethylsilyl)-5-(trifluoromethyl)-1H-indole

생성물 1

HCID 120301362-(5-(trifluoromethyl)-1H-indol-3-yl)ethanamine

시약·촉매·용매 1

HCID 887Methanol용매

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온도
70 °C

실험 절차

A mixture of 3-(2-azidoethyl)-2-(triethylsilyl)-5-(trifluoromethyl)-1H-indole (0.400 g; 1.09 mmol) and triphenylphosphine (0.427 g; 1.63 mmol) in methanol (5 mL) was stirred at 70° C. for 2 hours. The reaction mixture was concentrated under reduced pressure and the crude material was dissolved in a solution of tetrabutylamonium fluoride (3.26 mL, 1M) in THF, stirred at room temperature for 36 hours, and concentrated under reduced pressure. The crude material was used without any further purification.

후처리

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. dissolutionthe crude material was dissolved in a solution of tetrabutylamonium fluoride (3.26 mL, 1M) in THF
  3. stirringstirred at room temperature for 36 hours
  4. concentrationconcentrated under reduced pressure
  5. customThe crude material was used without any further purification

출처 및 근거

ORD 기록
ord-6a9b407d595d4ebb81db5c8e6da875a0
출처 데이터셋
uspto-grants-2016_02
특허 번호
US09266832B2

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