Sodium Hydroxide → 4-(3-Fluorophenoxy)benzoic acid

HRID 1777579노트

반응식

HRID 1777579 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH:16]=[CH:17][CH:18]=1)[O:5][C:6]1[CH:15]=[CH:14][C:9]([C:10]([O:12]C)=[O:11])=[CH:8][CH:7]=1.[OH-].[Na+]>O.O1CCOCC1>[F:1][C:2]1[CH:3]=[C:4]([CH:16]=[CH:17][CH:18]=1)[O:5][C:6]1[CH:15]=[CH:14][C:9]([C:10]([OH:12])=[O:11])=[CH:8][CH:7]=1

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 67973924Methyl 4-(3-fluorophenoxy)benzoate

생성물 1

HCID 225734424-(3-Fluorophenoxy)benzoic acid

시약·촉매·용매 2

HCID 962Water용매HCID 312751,4-Dioxane용매

실험 절차

Methyl 4-(3-fluorophenoxy)benzoate (0.202 g; 0.880 mmol) was added to a mixture of NaOH in water (2 mL; 2M) and dioxane (1 mL) and stirred vigorously at room temperature overnight. The resulting mixture was concentrated under reduced pressure and dissolved in water. The aqueous layer was acidified with a solution of hydrogen chloride 6M and the precipitated product was collected by filtration to yield 0.200 g (quantitative) of the title compound as a grey solid which was used without further purification.

후처리

  1. concentrationThe resulting mixture was concentrated under reduced pressure
  2. dissolutiondissolved in water
  3. filtrationthe precipitated product was collected by filtration

출처 및 근거

ORD 기록
ord-46122efac23d448b9688b4a0fb87cf1d
출처 데이터셋
uspto-grants-2016_02
특허 번호
US09266832B2

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