2-(Dimethoxymethyl)-1,8-naphthyridine → 7-(Dimethoxymethyl)-1,2,3,4-tetrahydro-1,8-naphthyridine

HRID 1777851노트

반응식

HRID 1777851 반응식
[CH3:1][O:2][CH:3]([O:14][CH3:15])[C:4]1[CH:13]=[CH:12][C:11]2[C:6](=[N:7][CH:8]=[CH:9][CH:10]=2)[N:5]=1>O=[Pt]=O.C(O)C>[CH3:15][O:14][CH:3]([O:2][CH3:1])[C:4]1[N:5]=[C:6]2[C:11]([CH2:10][CH2:9][CH2:8][NH:7]2)=[CH:12][CH:13]=1

참가 물질

4

반응물 1

HCID 177501752-(Dimethoxymethyl)-1,8-naphthyridine2회

생성물 1

HCID 177501767-(Dimethoxymethyl)-1,2,3,4-tetrahydro-1,8-naphthyridine

시약·촉매·용매 2

HCID 345198Adams' catalyst촉매HCID 702Ethanol용매

반응 조건

온도
23 °C

실험 절차

The procedure described in J. Org. Chem., 2004, 69 (6), pp 1959-1966 was used. Into a 5-l pressure tank reactor (5 atm) was placed 2-(dimethoxymethyl)-1,8-naphthyridine (intermediate 5, 200 g, 979 mmol), ethanol (3 l), PtO2 (12 g). The reactor was evacuated and flushed three times with nitrogen, followed by flushing with hydrogen. The mixture was stirred overnight at 23° C. under an atmosphere of hydrogen. This reaction was repeated four times. The solids were filtered out and the resulting mixture was concentrated under vacuum to give the title compound as a yellow solid.

후처리

  1. customThe reactor was evacuated
  2. customflushed three times with nitrogen
  3. customby flushing with hydrogen
  4. filtrationThe solids were filtered out
  5. concentrationthe resulting mixture was concentrated under vacuum

출처 및 근거

ORD 기록
ord-4fe2d7741fb74394a96ef141f1e52c86
출처 데이터셋
uspto-grants-2016_02
특허 번호
US09266883B2

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