Water → HCID 84016145, 화합물

HRID 1778197노트

반응식

HRID 1778197 반응식
C([O:3][C:4]([C:6]1[CH:7]=[N:8][N:9]([CH3:18])[C:10]=1[O:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[O:5])C.[Li+].[OH-].O>C1COCC1.CO>[CH3:18][N:9]1[C:10]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[C:6]([C:4]([OH:5])=[O:3])[CH:7]=[N:8]1

참가 물질

5

반응물 3

HCID 962WaterHCID 3939Lithium HydroxideHCID 867185501-Methyl-5-phenoxy-1H-pyrazole-4-carboxylic acid ethyl ester

생성물 1

HCID 84016145HCID 84016145, 화합물

시약·촉매·용매 1

HCID 21899815MeOH tetrahydrofuran용매

실험 절차

1-Methyl-5-phenoxy-1H-pyrazole-4-carboxylic acid ethyl ester (22.6 g; 91.4 mmol) is dissolved in THF/MeOH (1/1) and LiOH in water (7.67 g; 183 mmol) is added. After 16 hours at ambient temperature the reaction mixture is washed with EtOAc. The aqueous layer is acidified with 1 N HCl and extracted with EtOAc. The organic layer is dried and evaporated.

후처리

  1. washAfter 16 hours at ambient temperature the reaction mixture is washed with EtOAc
  2. extractionextracted with EtOAc
  3. customThe organic layer is dried
  4. customevaporated

출처 및 근거

ORD 기록
ord-5f092d773f20464aab47acfdc40b6913
출처 데이터셋
uspto-grants-2016_02
특허 번호
US09266891B2

반응 노트

불러오는 중…