N-Iodosuccinimide → HCID 178493476, 화합물

HRID 1778650노트

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HRID 1778650 반응식
[I:1]N1C(=O)CCC1=O.[Cl:9][C:10]1[C:15]([O:16][CH3:17])=[CH:14][C:13]([O:18][CH3:19])=[C:12]([Cl:20])[C:11]=1[C:21]1[N:26]=[C:25]2[NH:27][N:28]=[CH:29][C:24]2=[CH:23][N:22]=1>CN(C)C=O.O>[Cl:9][C:10]1[C:15]([O:16][CH3:17])=[CH:14][C:13]([O:18][CH3:19])=[C:12]([Cl:20])[C:11]=1[C:21]1[N:26]=[C:25]2[NH:27][N:28]=[C:29]([I:1])[C:24]2=[CH:23][N:22]=1

참가 물질

5

반응물 2

HCID 120273N-IodosuccinimideHCID 867228036-(2,6-dichloro-3,5-dimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine

생성물 1

HCID 178493476HCID 178493476, 화합물수율 79.3%

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

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온도
40 °C

실험 절차

N-Iodosuccinimide (0.23 g, 1.0 mmol) was added to a solution of 6-(2,6-dichloro-3,5-dimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine (0.30 g) in N,N-dimethylformamide (5.0 mL). The reaction mixture was stirred at 40° C. overnight. The reaction mixture was diluted with water and quenched with aqueous Na2S2O3. The precipitates formed were filtered, washed with water, ether, and dried in vacuum to afford the desired product (0.33 g). LCMS (M+H)+=450.8/452.8.

후처리

  1. customquenched with aqueous Na2S2O3
  2. customThe precipitates formed
  3. filtrationwere filtered
  4. washwashed with water, ether
  5. customdried in vacuum

출처 및 근거

ORD 기록
ord-ec9633839d0b4a10960612dc61716fcc
출처 데이터셋
uspto-grants-2016_02
특허 번호
US09266892B2

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