N-Iodosuccinimide → 6-(3,5-dimethoxyphenyl)-3-iodo-1H-pyrazolo[4,3-b]pyridine

HRID 1778767노트

반응식

HRID 1778767 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[CH:12]=[C:13]3[NH:19][N:18]=[CH:17][C:14]3=[N:15][CH:16]=2)[CH:6]=[C:7]([O:9][CH3:10])[CH:8]=1.[I:20]N1C(=O)CCC1=O>C(Cl)Cl>[CH3:10][O:9][C:7]1[CH:6]=[C:5]([C:11]2[CH:12]=[C:13]3[NH:19][N:18]=[C:17]([I:20])[C:14]3=[N:15][CH:16]=2)[CH:4]=[C:3]([O:2][CH3:1])[CH:8]=1

참가 물질

4

반응물 2

HCID 120273N-IodosuccinimideHCID 867228626-(3,5-dimethoxyphenyl)-1H-pyrazolo[4,3-b]pyridine

생성물 1

HCID 1784934406-(3,5-dimethoxyphenyl)-3-iodo-1H-pyrazolo[4,3-b]pyridine수율 94.4%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

At r.t. to a solution of 6-(3,5-dimethoxyphenyl)-1H-pyrazolo[4,3-b]pyridine (0.38 g, 1.5 mmol) in methylene chloride (5 mL) was added N-iodosuccinimide (0.352 g, 1.56 mmol) with stirring. The mixture was stirred at r.t. overnight. Then the solvent was removed, the residue was treated with methanol. The solid was collected by filtration to afford the desired product (0.54 g) which was directly used in next step reaction without further purification. LCMS (M+H)+=382.1.

후처리

  1. stirringThe mixture was stirred at r.t. overnight
  2. customThen the solvent was removed
  3. additionthe residue was treated with methanol
  4. filtrationThe solid was collected by filtration

출처 및 근거

ORD 기록
ord-6f1f007be5fa4717a6fb2430a0f2221c
출처 데이터셋
uspto-grants-2016_02
특허 번호
US09266892B2

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