Hydrochloric Acid → HCID 86750808, 화합물

HRID 1780345노트

반응식

HRID 1780345 반응식
[Br:1][C:2]1[CH:3]=[C:4]([O:9][CH2:10][C@H:11]2[CH2:15][CH2:14][CH2:13][N:12]2C(OC(C)(C)C)=O)[CH:5]=[N:6][C:7]=1[Cl:8].[ClH:23]>O1CCOCC1>[ClH:8].[ClH:23].[Br:1][C:2]1[CH:3]=[C:4]([O:9][CH2:10][C@H:11]2[CH2:15][CH2:14][CH2:13][NH:12]2)[CH:5]=[N:6][C:7]=1[Cl:8]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 22872666HCID 22872666, 화합물

생성물 1

HCID 86750808HCID 86750808, 화합물

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

5-bromo-6-chloro-3-(1-BOC-2-(R)-pyrrolidinylmethoxy)pyridine from step 69a (150 mg) was stirred with HCl in dioxane (3 mL) at room temperature for 16 hours. The precipitate formed was triturated with ether, and the solid was dried under high vacuum to afford the title compound (99.2 mg). mp 230° C. MS (CDI/NH3) m/z 291/293 (M+H)+. 1 H NMR (D2O, 300 MHz) δ: 1.89-2.02 (m, 1h), 2.05-2.21 (m, 2H), 2.21-2.35 (m, 1H), 3.42 (t, J=7.2 Hz, 2H), 4/12 (m, 1H)), 4.25 (dd, J=7.8, 10.5 Hz, 1H), 4.47 (dd, J=3.2, 10.5 Hz, 1H), 7.90 (d, J=2.7 Hz, 1H), 8.13 (d, J=2.7 Hz, 1H). Anal. Calcd for C10H12N2OBrCl·2 HCl: C, 36.61; H, 3.99; N, 8.54. Found: C, 36.69; H, 3.91; N, 8.41. [α]25D =-14.80° (c 0.25, MeOH).

후처리

  1. customThe precipitate formed
  2. customwas triturated with ether
  3. customthe solid was dried under high vacuum

출처 및 근거

ORD 기록
ord-4c9d282246274d83a6000e020f8af454
출처 데이터셋
uspto-grants-1997_05
특허 번호
US05629325

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