Pyridine → HCID 18973686, 화합물

HRID 1780840노트

반응식

HRID 1780840 반응식
[CH:1]1([CH2:4][O:5][C:6]2[CH:7]=[C:8](O)[CH:9]=[CH:10][C:11]=2[O:12][CH:13]([F:15])[F:14])[CH2:3][CH2:2]1.N1C=CC=CC=1.S(Cl)(Cl)=O.[CH:27](Cl)(Cl)[Cl:28]>>[CH:1]1([CH2:4][O:5][C:6]2[CH:7]=[C:8]([CH:9]=[CH:10][C:11]=2[O:12][CH:13]([F:15])[F:14])[CH2:27][Cl:28])[CH2:3][CH2:2]1

참가 물질

5

반응물 4

HCID 1049PyridineHCID 6212ChloroformHCID 24386Thionyl ChlorideHCID 54134609HCID 54134609, 화합물

생성물 1

HCID 18973686HCID 18973686, 화합물

실험 절차

A solution of crude 3-cyclopropylmethoxy-4-difluoromethoxyphenyl alcohol (24.4 g) and pyridine (9.8 mL, 120 mmol) in chloroform (150 mL) under an argon atmosphere was treated with thionyl chloride (8.0 mL, 110 mmol) and the mixture was heated at reflux for 1 h. The solvent was removed, ether was added and the precipitate was removed by filtration. The filtrate was concentrated to a pale yellow oil (26 g).

후처리

  1. temperaturethe mixture was heated
  2. temperatureat reflux for 1 h
  3. customThe solvent was removed
  4. additionether was added
  5. customthe precipitate was removed by filtration
  6. concentrationThe filtrate was concentrated to a pale yellow oil (26 g)

출처 및 근거

ORD 기록
ord-aa781d988aae4b8081c468563e72552e
출처 데이터셋
uspto-grants-1997_05
특허 번호
US05631286

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