Hydrochloric Acid → (S)-2-amino-3-phenylpropan-1-ol hydrochloride

HRID 1781233

반응식

HRID 1781233 반응식
C(OC([NH:8]C(C1C=CC=CC=1)(O)CC)=O)(C)(C)C.[ClH:19].[C:20]1([CH3:26])[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.[O:27]1CCO[CH2:29][CH2:28]1>>[ClH:19].[NH2:8][C@@H:29]([CH2:26][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[CH2:28][OH:27]

참가 물질

5

반응물 4

HCID 313Hydrochloric AcidHCID 1140TolueneHCID 312751,4-DioxaneHCID 77504178Tert-butoxycarbonylamino-1-phenyl-propan-1-ol

생성물 1

HCID 69017766(S)-2-amino-3-phenylpropan-1-ol hydrochloride

실험 절차

A solution of 20.10 g (80.00 mmol) of (S)-2-(tert-butoxycarbonylamino-1-phenyl-propan-1-ol [J. Med. Chem. 33, 2707 (1990)] in 200 ml of a 4N solution of gaseous hydrogen chloride in anhydrous dioxane is stirred at room temperature for 30 min. After that, 60 ml of toluene are added and the mixture is concentrated in vacuo. This process is repeated a further two times and the residue is then triturated with a little ether, filtered off with suction and dried under high vacuum over KOH. 14.14 g (94% of theory) of the title compound are obtained as colourless crystals.

후처리

  1. concentrationthe mixture is concentrated in vacuo
  2. customthe residue is then triturated with a little ether
  3. filtrationfiltered off with suction
  4. dry with materialdried under high vacuum over KOH

출처 및 근거

ORD 기록
ord-ca41f281a28e42868be930447eb2eb4d
출처 데이터셋
uspto-grants-1997_05
특허 번호
US05633231

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