(5-Nitro-2-sulfanylphenyl)methanol → HCID 19045546, 화합물

HRID 1781379노트

반응식

HRID 1781379 반응식
[SH:1][C:2]1[CH:9]=[CH:8][C:7]([N+:10]([O-:12])=[O:11])=[CH:6][C:3]=1[CH2:4][OH:5].N1C=CC=CC=1[CH2:19][CH2:20][CH:21]1[CH2:26][C:25](=O)[CH2:24][CH2:23][NH:22]1>C(Cl)(Cl)Cl>[N+:10]([C:7]1[CH:8]=[CH:9][C:2]2[S:1][C:25]3([CH2:24][CH2:23][N:22]([CH2:19][CH2:20][C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][N:22]=4)[CH2:21][CH2:26]3)[O:5][CH2:4][C:3]=2[CH:6]=1)([O-:12])=[O:11]

참가 물질

4

반응물 2

HCID 54329580(5-Nitro-2-sulfanylphenyl)methanolHCID 86746766HCID 86746766, 화합물

생성물 1

HCID 19045546HCID 19045546, 화합물

시약·촉매·용매 1

HCID 6212Chloroform용매

반응 조건

온도
25 °C

실험 절차

2-Mercapto-5-nitrobenzyl alcohol (150 mg, 0.81 mmol) and 208 mg (0.80 mm) of N-[2-(2'-pyridyl ethyl]-4-piperidone was dissolved in 5 mL of CHCl3. HCl Gas was bubbled in to saturate the solution, the mixture stirred at 25° C. for 2 days, then diluted with water and the pH adjusted to 10.0 with 40% aqueous NaOH. Extraction with CHCl3 and drying the organic phase (Na2SO4) gave after concentration and recrystallization from ethyl acetate 75 mg of an orange solid.

후처리

  1. customHCl Gas was bubbled in
  2. concentrationto saturate the solution
  3. additiondiluted with water
  4. extractionExtraction with CHCl3
  5. dry with materialdrying the organic phase (Na2SO4)
  6. customgave
  7. concentrationafter concentration and recrystallization from ethyl acetate 75 mg of an orange solid

출처 및 근거

ORD 기록
ord-21f4820d09ec43eea37f1383b4e918e9
출처 데이터셋
uspto-grants-1997_05
특허 번호
US05633247

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