Sodium Hydroxide → 6-Cyano-4,4-diphenylhexanoic acid

HRID 1781503노트

반응식

HRID 1781503 반응식
[C:1]([CH2:3][CH2:4][C:5]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH2:6][CH2:7][C:8]([O:10]CC)=[O:9])#[N:2].[OH-].[Na+]>C(O)C>[C:1]([CH2:3][CH2:4][C:5]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)([C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1)[CH2:6][CH2:7][C:8]([OH:10])=[O:9])#[N:2]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 19610260Ethyl 6-cyano-4,4-diphenylhexanoate

생성물 1

HCID 190455936-Cyano-4,4-diphenylhexanoic acid수율 94.5%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
60 °C

실험 절차

To a solution of ethyl 6-cyano-4,4-diphenylhexanoate (25.5 g) in ethanol (400 ml) was added 1N-aqueous sodium hydroxide solution (120 ml) and the mixture was heated and stirred at 60° C. for 1 hour. After completion of the reaction, the reaction mixture was concentrated under reduced pressure and the group was made acidic to with 1N-hydrochloric acid and extracted with ethyl acetate (200 ml×2). The extract was washed with saturated aqueous sodium chloride solution, dried over anhydrous sodium sulfate, and concentrated to dryness. The group (25 g) was recrystallized from chloroform-hexane to provide the title compound (22 g) as white powder.

후처리

  1. temperaturethe mixture was heated
  2. customAfter completion of the reaction
  3. concentrationthe reaction mixture was concentrated under reduced pressure
  4. extractionextracted with ethyl acetate (200 ml×2)
  5. washThe extract was washed with saturated aqueous sodium chloride solution
  6. dry with materialdried over anhydrous sodium sulfate
  7. concentrationconcentrated to dryness
  8. customThe group (25 g) was recrystallized from chloroform-hexane

출처 및 근거

ORD 기록
ord-c45ce467eda245a8a90c7c579be52209
출처 데이터셋
uspto-grants-1997_05
특허 번호
US05633248

반응 노트

불러오는 중…