Sodium Hydroxide → HCID 9865634, 화합물

HRID 1781514노트

반응식

HRID 1781514 반응식
C([NH:3][CH2:4][C:5]([C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[CH2:6][CH2:7][CH2:8][N:9]1[CH2:14][CH2:13][CH:12]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH2:11][CH2:10]1)=O.[OH-].[Na+]>CO>[NH2:3][CH2:4][C:5]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)([C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[CH2:6][CH2:7][CH2:8][N:9]1[CH2:14][CH2:13][CH:12]([C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH2:11][CH2:10]1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 9888730HCID 9888730, 화합물

생성물 1

HCID 9865634HCID 9865634, 화합물수율 100.3%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of 1-(5-formylamino-4,4-diphenylpentyl)-4-phenylpiperidine (2.07 g) in methanol (50 ml) was added 1N-sodium hydroxide (30 ml) and the mixture was refluxed overnight. This reaction mixture was concentrated to dryness and the group was extracted using methylene chloride and water. The organic layer was washed with water, dried over anhydrous sodium sulfate, and concentrated to dryness to provide the title compound (1.94 g) as yellow powder.

후처리

  1. temperaturethe mixture was refluxed overnight
  2. concentrationThis reaction mixture was concentrated to dryness
  3. extractionthe group was extracted
  4. washThe organic layer was washed with water
  5. dry with materialdried over anhydrous sodium sulfate
  6. concentrationconcentrated to dryness

출처 및 근거

ORD 기록
ord-8f22d5e763004e2ebbd516fb90970a8d
출처 데이터셋
uspto-grants-1997_05
특허 번호
US05633248

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